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23). Choose File if you want to back up to a file. The frequency of hematopoietic stem cells is about 1 cell per 104 bone marrow cells, even lower than the frequency of intes- G-CSF IL-3, GM-CSF, SCF, IL-6 M-CSF IL-3, GM-CSF Epo, SCF Epo GM-CSF IL-3 CFU-E SCF, Tpo, IL-3, GM-CSF Pluripotent HSC Myeloid stem cell Lymphoid stem cell GM-CFC Eo-CFC BFU-E CFC-mega T-CFC Granulocytes (phagocytic immune cells) Monocytes (macrophage precursors) Eosinophils (immune cells active in allergic reactions, fighting parasites) Erythrocytes (red blood cells) Megakaryocytes (platelet-forming cells) T and B cells of the immune system Pluripotent hematopoietic stem cell (HSC) Pluripotent HSC IL-2, IL-7, IL-12, SDF-1, FLT-3 ligand, TNF-α, TGF-β1 B-CFC FIGURE 22-5 Formation of differentiated blood cells from hematopoietic stem cells in the bone marrow.

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